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. 2024 May 28;31(10):1580–1588. doi: 10.1038/s41594-024-01323-5

Fig. 6. Lesion verification strategies of XPD.

Fig. 6

a, Lesion-stalled XPD (green) upon cross-link encounter. XPD and DNA are shown in cartoon mode and the interstrand cross-link lesion is shown as spheres. Relevant backbone phosphate positions relative to the lesion are indicated (P-1 and P0), where P0 marks the first phosphate from the lesion in the 3′ direction. R111, Y191 and R195 from C. thermophilum correspond to R112, Y192 and R196 in human XPD. b, Lesion-stalled XPD (light blue) upon 6–4 PP lesion encounter. XPD and DNA are shown in cartoon mode and the 6–4 PP lesion is shown as spheres. Relevant backbone phosphate positions relative to the lesion are indicated (P0 and P1). c, Lesion-stalled XPD (gray) upon CPD lesion encounter. XPD and DNA are shown in cartoon mode and the CPD lesion is shown as spheres. Relevant backbone phosphate positions relative to the lesion are indicated (P0, P1 and P4). b and c show representative end states of the molecular dynamics simulations from a previous study31.