TABLE 4.

Top 20 ADRs of two DNA methylation inhibitors.

Azacitidine (N = 17,925)		Decitabine (N = 5,838)
ADR	Report rate (%)	ADR	Report rate (%)
Febrile neutropenia	10.18	Myelosuppression	11.66
Neutropenia	6.67	Neutropenia	9.30
Myelosuppression	6.14	Febrile neutropenia	8.12
Thrombocytopenia	6.03	Thrombocytopenia	7.66
Anaemia	4.65	Leukopenia	5.24
Pancytopenia	3.04	Anaemia	3.82
Leukopenia	2.05	Pancytopenia	2.95
Cytopenia	1.60	Bone marrow failure	0.65
Bone marrow failure	0.59	Cytopenia	0.58
Haematotoxicity	0.57	Agranulocytosis	0.53
Agranulocytosis	0.51	Granulocytopenia	0.34
Leukocytosis	0.36	Haematotoxicity	0.31
Disseminated intravascular coagulation	0.26	Leukocytosis	0.27
Granulocytopenia	0.21	Thrombocytosis	0.17
Platelet disorder	0.19	Bicytopenia	0.15
Febrile bone marrow aplasia	0.18	Splenomegaly	0.14
Splenomegaly	0.16	Erythropenia	0.10
White blood cell disorder	0.13	Coagulopathy	0.09
Thrombocytosis	0.12	Disseminated intravascular coagulation	0.09
Haemolysis	0.11	Haemolytic anaemia	0.09