TABLE 6.
Different ADRs among two DNA methylation inhibitors.
| System organ classes | Azacitidine | Decitabine |
|---|---|---|
| Blood and lymphatic system disorders | White blood cell disorder, Platelet disorder, Febrile bone marrow aplasia, Disseminated intravascular coagulation | Bicytopenia |
| Cardiac disorders | Atrial flutter, Cardiac failure acute, Angina pectoris, Cardiac disorder, Pericarditis, Cardiovascular disorder | Palpitations, Left ventricular dysfunction, Cardiomyopathy |
| Congenital, familial and genetic disorders | ||
| Ear and labyrinth disorders | ||
| Endocrine disorders | ||
| Eye disorders | Vision blurred | |
| Gastrointestinal disorders | Ascites, Haematochezia, Upper gastrointestinal haemorrhage, Gastrointestinal disorder | Proctalgia, Haemorrhoids, Ileus, Dry mouth |
| General disorders and administration site conditions | Injection site pain, Injection site reaction, Injection site erythema | Oedema, Drug ineffective for unapproved indication, Chest discomfort |
| Hepatobiliary disorders | Hepatic failure, Liver disorder, Cholecystitis | |
| Immune system disorders | Acute graft versus host disease | Acute graft versus host disease in intestine, Acute graft versus host disease in skin, Chronic graft versus host disease |
| Infections and infestations | Bronchitis, COVID-19, Sinusitis, Clostridium difficile colitis | Device related infection, Nasopharyngitis, Enterococcal infection, Candida infection |
| Injury, poisoning and procedural complications | Intentional product use issue | Product storage error |
| Investigations | Neutrophil count abnormal, Blast cell count increased, Transaminases increased, Full blood count decreased, Blood lactate dehydrogenase increased, Platelet count abnormal, Haemoglobin abnormal | Blood culture positive, Liver function test abnormal, Blood alkaline phosphatase increased, Lymphocyte count decreased, Hepatic enzyme increased, Haematocrit decreased, Body temperature increased |
| Metabolism and nutrition disorders | Hypophosphataemia, Failure to thrive, Diabetic ketoacidosis, Hypophagia, Cachexia, Hypoalbuminaemia, Hypervolaemia, Hypocalcaemia, Acidosis | |
| Musculoskeletal and connective tissue disorders | Joint swelling | |
| Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Transformation to acute myeloid leukaemia, Myelodysplastic syndrome transformation, Differentiation syndrome, Chronic myelomonocytic leukaemia, Myelofibrosis | Acute myeloid leukaemia refractory |
| Nervous system disorders | Loss of consciousness | Lethargy, Tremor, Encephalopathy, Paraesthesia, Hypoaesthesia, Posterior reversible encephalopathy syndrome |
| Pregnancy, puerperium and perinatal conditions | ||
| Product issues | ||
| Psychiatric disorders | Depression | Delirium |
| Renal and urinary disorders | Renal disorder | Pollakiuria |
| Reproductive system and breast disorders | ||
| Respiratory, thoracic and mediastinal disorders | Lung disorder, Respiratory disorder, Dyspnoea exertional | Rhinorrhoea, Pulmonary haemorrhage, Sputum increased |
| Skin and subcutaneous tissue disorders | Skin lesion, Skin reaction, Pyoderma gangrenosum, Rash erythematous, Rash pruritic, Rash macular | |
| Social circumstances | Blood product transfusion dependent | |
| Surgical and medical procedures | ||
| Vascular disorders | Thrombosis |