TABLE 1.
p53 mutations in Tax-induced tumors
| Mutationa | Frequency | No. documentedb |
|---|---|---|
| Primary tumors | 3/7 (43%)c | |
| P203A | 2/7 (29%) | |
| N239S | 2/7 (29%) | |
| Disseminated tumors | 10/11 (91%)d | |
| P203A | 3/11 (27%) | 25 |
| E228G | 5/11 (45%) | 19 |
| N239S | 3/11 (27%) | 68 |
| G244R | 3/11 (27%) | 106 |
Primary and disseminated tumor tissues from a total of seven different mice were analyzed for p53 mutations. Except for positions 203 (Ala in murine p53 and Val in human p53) and 228 (Gly in murine p53 and Asp in human p53), the amino acid sequences are identical in murine and human p53.
The Universal Mutation p53 database, which contains over 10,000 p53 mutations identified in all types of human cancers, was utilized to calculate the number of times a nucleotide change has been identified at that location.
One primary tail tumor contained both P203A and N239S mutations, and two tumors contained either a P203A or N239S mutation.
Two disseminated tumors contained both E228G and N239S mutations and two contained both P203A and E228G.