Table 2.

Exacerbation Pattern on Progression With Osimertinib

Progression Pattern	Asymptomatic and No Clinical Exacerbation	Symptomatic and No Clinical Exacerbation	Clinical Exacerbationa	Total
CNS metastasis only	16	4	17	37
	(4.7)	(1.2)	(4.9)	(10.8)
Oligoprogressionb	109	30	17	156
	(31.7)	(8.7)	(4.9)	(45.4)
Multiple organs	70	39	42	151
	(20.4)	(11.3)	(12.2)	(43.9)
Total	195	73	76	344
	(56.7)	(21.2)	(22.1)	(100)

Note: All values are n (%).

CNS, central nervous system; PS, performance status.

^aClinical exacerbation was defined as a decline in the PS and or or exacerbation threatening major organs (carcinomatous lymphangiosis, bone marrow metastasis, carcinomatous meningitis, liver metastasis with liver damage, etc.).

^bSingle organ other than the CNS (up to three per organ).