Fig. 3.

Model-estimated proportions of patients achieving DLQI Item 1 (itchy, sore, painful, or stinging skin)^a = 0. A Over 16 weeks. B Over 2 years, a mixed-effects logistic regression model used data pooled across all trial visits and treatments over A 16 weeks and B 2 years of BE RADIANT to estimate the proportions of patients achieving DLQI Item 1 = 0 at specific PASI improvement levels. Error bars correspond to 95% CIs. The curves correspond to model estimates calculated with baseline DLQI Item 1 score equal to the baseline median for the respective populations (16 weeks: 2.0 [all randomised patients]; 2 years: 2.0 [patients who entered the OLE]). ^aQuestion: ‘over the last week, how itchy, sore, painful, or stinging has your skin been’; answer: ‘not at all’ (0), ‘a little’ (1), ‘a lot’ (2), or ‘very much’ (3). CI confidence interval, DLQI Dermatology Life Quality Index, OLE open-label extension, PASI Psoriasis Area and Severity Index