Fig. 4.

Model-estimated proportions of patients achieving P-SIM itching = 0. A Over 16 weeks. B Over 2 years. A mixed-effects logistic regression model used data pooled across all trial visits and treatments over A 16 weeks and B 2 years of BE RADIANT to estimate the proportions of patients achieving P-SIM itching = 0 at specific PASI improvement levels. Error bars correspond to 95% CIs. The curves correspond to model estimates calculated with baseline P-SIM itching score equal to the baseline median for the respective populations (16 weeks: 7.0 [all randomised patients]; 2 years: 7.0 [patients who entered the OLE]). CI confidence interval, OLE open-label extension, PASI Psoriasis Area and Severity Index, P-SIM Psoriasis Symptoms and Impacts Measure