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. 2024 Aug 29;43(20):4786–4804. doi: 10.1038/s44318-024-00210-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Figure EV3 — (A) Distribution of genomic DNA iM structures across the human genome features. Left panels show the distribution of iM pulldown relative to all TSS regions (Refseq). Centre panels show the percentage of occupancy of iM sites relative to TSS distance. Right panels represent the percentage in relationship with the common gene body features. (B) log₂ fold enrichment of iM regions distributed across most common genomic annotations. (C) Relative immunoprecipitated DNA mean signal normalised (sample-input) in relationship to RefSeq gene coordinates. (D) Genomic partition of replication zones (analyses based on repetition of up transition zones (UTZ), early replication zones (ERD), down transition zones (DTZ) and late replication domains (LRD); Tag count heatmaps of G4 (Chambers et al, 2015) (upper panels) and iMs (lower panels; two biological replicates shown). (E) Overlap of iM regions found in DNA purified from MCF7 replicates and previously reported MCF7 TAD boundaries (GSE66733).