Figure 5.

rRNA subtype expression is tissue specific and differs between tissues derived from the ectoderm and endoderm lineages

(A) Schematic representation of the GTEx analysis focusing on cortex versus stomach comparison. We map rRNA reads from different samples to rRNA subtypes. Per rRNA subtype, we illustrate variant expression comparison between tissues. Upper panel: boxplot comparing rRNA subtype expression in cortex and stomach samples. Bottom panel: median rRNA subtype expression across all tissues. Cortex and stomach are annotated, and all ectoderm and endoderm tissues are highlighted in blue/red.

(B) Upper panel: boxplot comparing the expression levels of the rRNA subtype with the haplotype G,AG,C (positions 60, 3513, 4913) in cortex and testis samples. Bottom panel: scatterplot showing the median frequency of the rRNA subtype from the upper panel across all tissues. Tissues derived from ectoderm are marked in blue, tissues derived from endoderm in red, and other tissues in gray. The cortex and testis that were shown in the top panel are annotated with a line.

(C) Same as (B) for the rRNA subtype with the haplotype A,GGCAG,U highlighting gastroesophageal junction and cerebellum samples.

(D) Same as (B) for the rRNA subtype with the haplotype G,GGCAG,C highlighting smooth muscle and spinal cord samples.