Skip to main content
. 2013 Mar 28;2013(3):CD000504. doi: 10.1002/14651858.CD000504.pub4

Troche 1995.

Methods Randomised controlled trial
Participants Infants born at 25 to 30 weeks' gestation with respiratory distress, an umbilical artery catheter in situ, and an anticipated need for mechanical ventilation for at least 3 days. Infants with asphyxia or respiratory failure despite ventilatory support were excluded
Setting: University of Boston, USA
Interventions Minimal enteral nutrition (N = 16) vs. enteral fasting (N = 13)
Infants in the minimal enteral nutrition group received maternal breast milk or standard formula beginning within 24 hours after birth at a rate of 0.5 to 1.0 ml/hour until the umbilical artery catheter was removed. Controls were fasted until the umbilical arterial catheter was removed. Both groups received parenteral nutrition beginning on day 3
Outcomes Feeding tolerance; days to full enteral feeding
Incidence of necrotising enterocolitis
Time to regain birth weight
Mortality
Notes In infants < 800g at birth, feeds were given by continuous infusion, for those > 800 g feeds were given as boluses
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Random numbers table
Allocation concealment (selection bias) Unclear risk Unclear
Blinding (performance bias and detection bias) 
 All outcomes High risk Not stated but likely that care givers and investigators were aware of intervention group after allocation
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not stated
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 2 infants developed necrotising enterocolitis but were then subsequently excluded from growth data