TABLE 2.
Structures of the sialic acid parts of chemical derivatives of NeuGc-GM3 and NeuAcα3-neolactotetraosylceramide
| Name of derivative | Modification of C-1–COOH group | Modification of C-7–glycerol side chain- (CHOH)2-CH2OH | Binding on TLC plates
|
||
|---|---|---|---|---|---|
| TLP
|
DLP (SA11 and NCDV) | ||||
| SA11 | NCDV | ||||
| NeuGc-GM3 alcohol | -CH2OH | ± | − | + | |
| NeuGc-GM3 amide | -CONH2 | + | ± | + | |
| NeuGc-GM3 methylamide | -CONHCH3 | + | ± | + | |
| NeuGc-GM3 ethylamide | -CONHCH2CH3 | − | ± | ± | |
| NeuGc-GM3 propylamide | -CONHCH2CH2CH3 | − | ± | ± | |
| NeuGc-GM3 benzylamide | -CONHCH2C6H5 | ± | ± | + | |
| C-8–NeuAcα3–neolactotetraosylceramide | -CHOH-CH2OH | − | − | − | |
| C-7–NeuAcα3–neolactotetraosylceramide | -CH2OH | − | − | − | |