Figure 6.

Temporal progression of age‐related molecular events in the NHP female heart's left ventricle. A) Cardiac hypertrophy‐related and B) ECM‐induced pathways with absolute z‐score greater than 2. Bars represent the z‐score and boxplot the vertices of the transcripts with quadratic behavior from each pathway (in red transcripts upregulated with age and in green transcripts downregulated with age). C) Comparison of baboon ages (and human equivalent age) from the calculation of the tipping points predicting the ages at which the transcriptomics aging‐related changes for different pathways, periods of GAG accumulation, fast accumulation, and increased cardiomyocyte size. D) Schematic representation of the novel molecular proposed mechanisms associated with cardiac aging. ECM – extracellular matrix; GAG – glycosaminoglycan; OXPHOS – oxidative phosphorylation; PDH – pyruvate dehydrogenase; Pw. – pathway; Sig. – signaling; TCA – tricarboxylic acid.