Table 5. PFOC outcomes for very remote CVE/SE.

	<24 months (N=441)	≥24 months (N=55)	P value
Age	50 (41–58)	53 (42–63)	0.234
Female sex	180 (40.9)	25 (45.5)	0.416
Time from CVE/SE to PFOC (months)	4.7 (2.4–9.4)	55.0 (35.4–94.5)	0.001
RoPE score	2.0 (1.2–4.1)	2.6 (1.4–6.7)	0.235
One-year CVE/SE recurrence	8 (2.1)	0 (0)	0.300
Last available follow-up CVE/SE recurrence	13 (3.4)	2 (4.2)	0.770

CVE/SEcerebrovascular event or systemic embolismPFOCpatent foramen ovale closureRoPERisk of Paradoxical Embolism