Fig. 3.

Activation of pro-inflammatory pathways and increased tau phosphorylation in obese mice after sevoflurane exposure. (a) Significant reduction in pAMPK and up-regulation of pJNK and c-jun (Ser 73) in the obese group (n = 4). (b) Increased tau phosphorylation (Ser 199 and 396) in the obese group (n = 4). All data are presented as the mean and SEM and presented as band densities normalized to their endogenous protein control. *p < 0.05, **p < 0.01, ***p < 0.001 in comparison to the respective control groups. Values were analysed using the unpaired t-test