Fig. 5.
STRING protein–protein interaction network of 195 eligible discordant set points of gene expression that could facilitate strategies to improve hCiC neo-cartilage formation. A Significant STRING protein–protein interaction network (P < 1 × 10−16) among downregulated genes in hCiC derived neo-cartilage relative to hPAC (N = 140). B Significant STRING protein–protein interaction network (P = 8.1 × 10−3) among of genes that were significantly upregulated in hCiC derived neo-cartilage relative to hPAC (N = 55). The edges indicate both functional and physical protein associations, with selected genes of Fig. 6 indicated in bold. Line thickness indicates the strength of data support. Minimum required interaction score = medium confidence (0.400)