Table 4.

Overview of the eight different sets of simulations that were performed in this study

Experiment	Geometry	BC	Other changes	# Simulations
Base model 1	Subject specific	Generic	None	47
Base model 2	Subject specific	Subject specific	None	47
Base model 3	Average	Subject specific	None	47
Variation 1	Average	Generic	Pericapillary resistance set to either (in mmHg/(ml/min)): $R_{\mathit{pc}}=9.2·{10}^{-3}$ (Base), $R_{\mathit{pc}}=3.32·{10}^{-4}$ (Pizzo) or $R_{\mathit{pc}}=32.24$ (High).	3
Variation 2	Average	Generic	CSF outflow resistances changed to (in mmHg/(ml/min)): $R_{\mathit{DS}}=10.81,R_{\mathit{crib}}=67$ (Base), $R_{\mathit{DS}}=21.62,R_{\mathit{crib}}=67$ (High), $R_{\mathit{DS}}=5.41,R_{\mathit{crib}}=67$ (Low).	3
Variation 3	Average	Generic	Changes to capillary filtration: ${\omega }_{c,pc}=8.48·{10}^{-10}$ Pa$_{}^{-1}$s$_{}^{-1}$ , no constant filtration (Base), or ${\omega }_{c,pc}=0$ Pa$_{}^{-1}$s$_{}^{-1}$ , with constant filtration rate of 0.16 ml/min at ventricles (Alternate).	2
Variation 4	Average	Generic	Perivascular transfer coefficients changed to (units Pa$_{}^{-1}$s$_{}^{-1}$): ${\omega }_{pa,e}=1.86·{10}^{-7}$, ${\omega }_{e,pv}=1.65·{10}^{-7}$, ${\omega }_{pc,e}={10}^{-10}$ (Base), ${\omega }_{pc,e}=5·{10}^{-7}$, the rest unchanged (Case 1), ${\omega }_{pa,e}=1.86·{10}^{-6}$, ${\omega }_{e,pv}=1.65·t{o}^{-6}$, ${\omega }_{pc,e}={10}^{-8}$ (Case 2), ${\omega }_{pa,e}={10}^{-10}$, ${\omega }_{e,pv}$ unchanged, ${\omega }_{pc,e}=1.86·{10}^{-7}$ (Case 3), ${\omega }_{pa,e}$ halved, ${\omega }_{e,pv}$ halved, ${\omega }_{pc,e}$ unchanged (Case 4).	5
Variation 5	Average	Generic	Changes to extracellular permeability (Units nm$_{}^2$): ${\kappa }_e=20$ (Base), ${\kappa }_e=200$ (High), ${\kappa }_e=2000$ (Very high).	3