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. 2024 Sep 9;15(10):e02360-24. doi: 10.1128/mbio.02360-24

TABLE 3.

Description of the National Institutes of Health cohorta,b

Sample ID Group Gender Age bracket Direct microbiological evidence of Bb infection Interval sample from start of antibiotic therapy (days) Lyme EIA (C6 Peptide ELISA or VlsE/PepC10) Western blot IgM Western blot IgG Two-tier testing Cohort differential model Match observed/predicted
LA_01 Lyme Arthritis Female >55 POS >45 POS NEG POS POS LA YES
LA_02 Lyme Arthritis Male 41–55 POS pre-therapy POS NEG POS POS LA YES
LA_03 Lyme Arthritis Female <20 POS >45 POS NEG POS POS LA YES
LA_04 Lyme Arthritis Male >55 POS >45 POS POS POS POS LA YES
LA_05 Lyme Arthritis Male 20–40 POS 3 to 8 POS POS POS POS LA YES
LA_06 Lyme Arthritis Male <20 POS 22 to 45 POS NEG POS POS LA YES
LA_07 Lyme Arthritis Male 41–55 NA >45 POS NEG POS POS LA YES
LA_08 Lyme Arthritis Male <20 POS 22 to 45 POS NEG POS POS LA YES
LA_09 Lyme Arthritis Male 20–40 NA >45 POS NEG POS POS LA YES
LA_10 Lyme Arthritis Male 41–55 NA 22 to 45 POS NEG POS POS LA YES
LA_11 Lyme Arthritis Female 41–55 NA 22 to 45 POS POS POS POS LA YES
LA_12 Lyme Arthritis Female 41–55 NA >45 POS NEG POS POS LA YES
LA_13 Lyme Arthritis Female >55 NEG >45 POS POS POS POS LA YES
LA_14 Lyme Arthritis Male 41–55 NEG >45 POS NEG POS POS LA YES
LA_15 Lyme Arthritis Male >55 POS 22 to 45 POS POS POS POS LA YES
LA_16 Lyme Arthritis Male >55 NA >45 POS POS POS POS LA YES
LA_17 Lyme Arthritis Male >55 POS >45 POS NEG POS POS LA YES
LA_18 Lyme Arthritis Female <20 POS three to 8 POS NEG POS POS LA YES
LA_19 Lyme Arthritis Male >55 POS >45 POS NEG POS POS LA YES
LA_20 Lyme Arthritis Male >55 NEG >45 POS POS POS POS LA YES
LA_21 Lyme Arthritis Female 41–55 NA >45 POS POS POS POS LA YES
LA_22 Lyme Arthritis Male 20–40 POS 22 to 45 POS NEG POS POS LA YES
LA_23 Lyme Arthritis Male 41–55 NA >45 POS NEG POS POS LA YES
LA_24 Lyme Arthritis Male >55 POS >45 POS POS POS POS LA YES
LA_25 Lyme Arthritis Male 41–55 NA 22 to 45 POS POS POS POS LA YES
LA_26 Lyme Arthritis Female 41–55 NEG >45 POS NEG POS POS LA YES
LA_27 Lyme Arthritis Female 20–40 POS 22 to 45 POS POS POS POS LA YES
MEM_01 Multiple EM Female 41–55 NA 22 to 45 POS POS POS POS MEM YES
MEM_02 Multiple EM Male >55 NA >45 POS POS NEG NEG SEM-C NO
MEM_03 Multiple EM Female >55 POS 22 to 45 POS POS POS POS SEM-C NO
MEM_04 Multiple EM Female >55 NA 22 to 45 POS POS POS POS MEM YES
MEM_05 Multiple EM Male 41–55 NA 9 to 21 POS POS POS POS LA NO
MEM_06 Multiple EM Female 41–55 NA 22 to 45 POS POS POS POS MEM YES
MEM_07 Multiple EM Female 41–55 NA >45 POS POS POS POS MEM YES
MEM_08 Multiple EM Male 41–55 NA 22 to 45 POS POS NEG POS MEM YES
MEM_09 Multiple EM Male 20–40 NA 22 to 45 POS POS NEG NEG MEM YES
MEM_10 Multiple EM Female 20–40 NA 22 to 45 POS POS NEG NEG MEM YES
MEM_11 Multiple EM Female >55 NEG 22 to 45 POS POS NEG NEG MEM YES
MEM_12 Multiple EM Female 41–55 POS 22 to 45 POS POS NEG NEG SEM-C NO
MEM_13 Multiple EM Female 41–55 NA 22 to 45 POS POS NEG POS ALNB NO
ALNB_01 Acute LNB Male >55 NEG 1 to 2 POS NEG POS POS LA NO
ALNB_02 Acute LNB Male 41–55 NEG 1 to 2 POS POS NEG POS Acute LNB YES
ALNB_03 Acute LNB Male 20–40 NEG 1 to 2 POS POS POS POS Acute LNB YES
ALNB_04 Acute LNB Female 20–40 NEG 3 to 8 POS POS NEG POS Acute LNB YES
ALNB_05 Acute LNB Female 41–55 NEG 9 to 21 POS POS POS POS Acute LNB YES
ALNB_06 Acute LNB Male 20–40 NEG 9 to 21 POS POS POS POS Acute LNB YES
ALNB_07 Acute LNB Male 20–40 NEG 3 to 8 POS POS NEG POS Acute LNB YES
ALNB_08 Acute LNB Male 41–55 NEG 1 to 2 POS POS NEG POS Acute LNB YES
ALNB_09 Acute LNB Male <20 NEG Pre-therapy POS POS POS POS Acute LNB YES
ALNB_10 Acute LNB Male 20–40 NEG 9 to 21 POS POS NEG NEG Acute LNB YES
ALNB_11 Acute LNB Male >55 NEG Pre-therapy POS POS POS POS MEM NO
ALNB_12 Acute LNB Male 41–55 NEG 3 to 8 POS POS NEG POS Acute LNB YES
ALNB_13 Acute LNB Female 41–55 NEG 9 to 21 POS POS NEG POS Acute LNB YES
ALNB_14 Acute LNB Male 20–40 NEG 9 to 21 POS POS POS POS Acute LNB YES
ALNB_15 Acute LNB Male <20 NEG Pre-therapy POS POS POS POS Acute LNB YES
SEM-C_01 Single EM Male 20–40 NA >45 POS NEG NEG NEG MEM NO
SEM-C_02 Single EM Female >55 NA 22 to 45 POS POS NEG POS Single EM YES
SEM-C_03 Single EM Female >55 NA >45 POS NEG NEG NEG Single EM YES
SEM-C_04 Single EM Male <20 NA 22 to 45 POS POS NEG NEG Single EM YES
SEM-C_05 Single EM Female >55 POS 22 to 45 POS POS NEG POS Single EM YES
SEM-C_06 Single EM Female 41–55 NEG 22 to 45 POS POS NEG NEG Single EM YES
SEM-C_07 Single EM Female 20–40 NEG 22 to 45 POS POS NEG NEG Single EM YES
SEM-C_08 Single EM Male >55 NA 9 to 21 POS POS POS POS Single EM YES
SEM-C_09 Single EM Female <20 POS 3 to 8 POS NA NA NA Single EM YES
SEM-C_10 Single EM Female 20–40 POS 22 to 45 POS POS NEG NEG Single EM YES
SEM-C_11 Single EM Female 41–55 POS 22 to 45 POS NEG POS POS Single EM YES
SEM-C_12 Single EM Female >55 NA 22 to 45 POS NEG NEG NEG Single EM YES
SEM-C_13 Single EM Male 20–40 NA 22 to 45 POS POS NEG NEG Single EM YES
SEM-C_14 Single EM Male >55 NA >45 POS POS NEG NEG Single EM YES
SEM-C_15 Single EM Female >55 POS 22 to 45 POS NEG POS POS Single EM YES
SEM-C_16 Single EM Female 41–55 NA 22 to 45 NEG NA NA NA Single EM YES
SEM-C_17 Single EM Female >55 POS >45 POS POS NEG NEG Single EM YES
SEM-C_18 Single EM Male >55 NA >45 POS POS NEG NEG MEM NO
SEM-C_19 Single EM Female 41–55 POS 22 to 45 POS POS NEG NEG Single EM YES
SEM-C_20 Single EM Male 20–40 POS 22 to 45 NEG NA NA NA Single EM YES
SEM-C_21 Single EM Female 20–40 NEG 22 to 45 POS POS POS POS LA NO
SEM-C_22 Single EM Male 41–55 NEG 22 to 45 NEG NA NA NA Single EM YES
SEM-C_23 Single EM Male >55 NA >45 POS POS NEG NEG Single EM YES
SEM-C_24 Single EM Female 20–40 NA 22 to 45 POS POS NEG POS Single EM YES
SEM-C_25 Single EM Female 20–40 NEG Pre-therapy NEG NA NA NA Single EM YES
SEM-C_26 Single EM Male 41–55 NA 22 to 45 NEG NA NA NA SEM-A NO
SEM-C_27 Single EM Male >55 NEG 22 to 45 POS POS POS POS SEM-A NO
a

Direct microbiological evidence of Borrelia burgdorferi infection by culture and/or PCR in blood, synovial fluid, skin biopsies, and/or cerebrospinal fluid.

b

NA: data not available; POS: positive; NEG: negative. LA: Lyme arthritis; MEM: multiple erythema migrans; ALNB: acute Lyme neuroborreliosis; SEM-C: single erythema migrans convalescent.