TABLE 1.
Summary of behavior of polymerase mutant viruses
| Virus | Growtha | Pol proteinb | Pol at focic | PML at focid |
|---|---|---|---|---|
| KOS | +++ | +++ | +++ | +++ |
| V462A | +++ | +++ | +++ | +++ |
| Arar9 | +++ | +++ | +++ | +++ |
| 615.8 | +++ | +++ | +++ | +++ |
| F891C | +++ | +++ | +++ | +++ |
| PAAr5 | +++ | +++ | +++ | +++ |
| Y7 | +++ | +++ | +++ | +++ |
| YD12 | +++ | +++ | +++++ | +++ |
| HP66 | — | — | — | — |
| ΔX17 | — | — | — | — |
| ΔX14 | — | — | — | — |
| ΔS1.1 | — | — | — | — |
| 7E4A | — | — | — | — |
| 6C4 | — | ++ | — | — |
| E460D | — | +++ | — | — |
| G464V | — | +++ | — | — |
| tsC4 | — | +++ | — | — |
| tsC7 | — | +++ | + | ++ |
a
Indicates ability of mutant virus to form plaques on noncomplementing cell lines. +++++, higher than wild-type levels; +++, wild-type levels; ++, slightly lower than wild-type levels; +, significantly lower than wild-type levels; —, undetectable.
b
Indicates ability of mutant virus to synthesize Pol protein detectable by Western blot analysis.
c
Indicates whether Pol protein is detectable at viral prereplicative sites.
d
Indicates whether PML protein is detectable at viral prereplicative sites.