FIG. 1.
EBV lytic replication disrupts PML bodies. EBV-positive cells (D98/HE-R-1) were transfected with expression plasmids for either Z (A and B) or R (C and D). At 48 h posttransfection, cells were fixed and immunostained with either anti-Z (monoclonal) (A), anti-R (monoclonal) (C), or anti-PML protein (polyclonal) (B and D) antibodies. Arrows indicate cells that are positively expressing Z or R.