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Z expression induces a loss of PML protein isoforms. EBV-negative A549 cells were mock infected (lane 1) or infected with an adenovirus expressing either LacZ (lane 2), Z (lane 3), or R (lane 4). Cells were harvested 48 h postinfection, and Western blot analysis was performed with anti-PML protein monoclonal antibody. PML isoforms lost after Z expression are indicated by asterisks.
