Table 3.

Summary of body composition data in control and HFD young and aged male mice

	Young				Aged
	WT CD	SSPN−/− CD	WT HFD	SSPN−/− HFD	WT CD	SSPN−/− CD	WT HFD	SSPN−/− HFD
n	3	6	5	6	6	7	5	8
	EchoMRI values (males)
%Total fat	17 ± 2.4	7.7 ± 1.2	38.4 ± 2.2a	33.6 ± 3.3b	25.7 ± 2.5	10.1 ± 1.2c	45.2 ± 1.5d	35.3 ± 0.7e,f
%Total lean	81.7 ± 2.2	88.7 ± 1.2	61.7 ± 2.5a	66.3 ± 3.3b	73.4 ± 2.0	83.7 ± 1.3c	54.8 ± 1.4d	60.0 ± 0.4e

Values are means ± SE; n, number of mice. CD, control diet; HFD, high-fat diet; SSPN^−/−, sarcospan deficient; WT, wild type. One-way ANOVA was used to compare differences between groups. ^aP < 0.05, WT CD vs. HFD (young) mice; ^bP < 0.05, SSPN^−/− CD vs. HFD (young) mice; ^cP < 0.05, WT vs. SSPN^−/− (aged) CD mice; ^dP < 0.05, WT CD vs. HFD (aged) mice; ^eP < 0.05, SSPN^−/− CD vs. HFD (aged) mice; ^fP < 0.05, WT vs. SSPN^−/− HFD (aged) mice. Significant groups: Fat (%): ****WT CD vs. HFD (young), ****SSPN^−/− CD vs. HFD (young), ****CD WT vs. SSPN^−/− (aged), ****WT CD vs. HFD (aged), ****vs. SSPN^−/− CD vs. HFD (aged), *WT HFD vs. SSPN^−/− HFD (aged); Lean (%): ****WT CD vs. HFD (young), ****SSPN^−/− CD vs. HFD (young), **CD WT vs. SSPN^−/− (aged), ****WT CD vs. HFD (aged), vs. ****SSPN^−/− CD vs. HFD (aged).