Table 3.
Clinical and laboratory characteristics of CA.ME.LI.A population stratified by glucose tolerance and BMI
| NFG/NBW | NFG/OWO | IFG/NBW | IFG/OWO | DM/NBW | DM/OWO | |
|---|---|---|---|---|---|---|
| n | 1,039 |
754 |
183 |
398 |
28 | 143 |
| Age, yr (P ≤ 0.0001) | 40.6 ± 13.6 | 48.9 ± 14 | 51.6 ± 14.5 | 55.9 ± 12 | 56.9 ± 13.1 | 62.1 ± 9.4 |
| Weight, kg (P ≤ 0.0001) | 60.9 ± 9.2 | 80.6 ± 12.7 | 64.7 ± 9.7 | 84.4 ± 13.0 | 63.8 ± 8.3 | 86.5 ± 16.3 |
| Height, cm (P = 0.07) | 166.4 ± 9.7 | 167.3 ± 10.4 | 168.1 ± 10.0 | 167.8 ± 10.0 | 167.4 ± 8.9 | 165.5 ± 10.4 |
| SBP, mmHg (P ≤ 0.0001) | 114.1 ± 14.7 | 125.6 ± 16.1 | 123.9 ± 17.3 | 133.1 ± 18.3 | 125.3 ± 19.1 | 138.2 ± 19.4 |
| DBP, mmHg (P ≤ 0.0001) | 72.3 ± 9.5 | 79.0 ± 9.5 | 75.7 ± 10.0 | 82.8 ± 10.1 | 74.1 ± 9.9 | 81.1 ± 10.9 |
| Waist circumference, cm (P ≤ 0.0001) | 81.8 ± 7.8 | 98.4 ± 9.3 | 86.1 ± 8.4 | 102.1 ± 10.3 | 83.7 ± 8.5 | 107.5 ± 12.6 |
| Glucose, mg/dL (P ≤ 0.0001) | 87.9 ± 6.7 | 90.9 ± 5.6 | 105.8 ± 6.1 | 107.9 ± 6.4 | 143.1 ± 40.5 | 159.0 ± 49.5 |
| Insulin, U/L (P ≤ 0.0001) | 4.3 ± 2.1 | 6.6 ± 3.4 | 5.7 ± 3.5 | 9.3 ± 7.4 | 9.0 ± 7.7 | 12.4 ± 10.4 |
| HOMA index (P ≤ 0.0001) | 0.9 ± 0.5 | 1.5 ± 0.8 | 1.5 ± 1.0 | 2.5 ± 2.1 | 3.1 ± 2.7 | 5.2 ± 6.1 |
| Total cholesterol, mg/dL (P ≤ 0.0001) | 198.1 ± 39.1 | 211.6 ± 40.0 | 209.0 ± 39.6 | 211.0 ± 40.8 | 196.5 ± 34.5 | 201.1 ± 40.7 |
| HDL cholesterol, mg/dL (P ≤ 0.0001) | 59.6 ± 13.4 | 53.0 ± 13.0 | 58.0 ± 14.1 | 49.6 ± 11.9 | 51.5 ± 14.1 | 46.7 ± 10.5 |
| LDL, mg/dL (P ≤ 0.0001) | 127.4 ± 30.8 | 144.0 ± 32.1 | 137.7 ± 33.2 | 144.2 ± 32.9 | 130.8 ± 27.8 | 137.4 ± 33.3 |
| Triglycerides, mg/dL (P ≤ 0.0001) | 85.1 ± 40.7 | 115.7 ± 67.6 | 99.4 ± 61.3 | 140.7 ± 88.1 | 121.0 ± 70.1 | 154.1 ± 106.9 |
| Hematocrit, % (P ≤ 0.0001) | 41.5 ± 3.7 | 42.5 ± 3.7 | 43.3 ± 3.5 | 43.6 ± 3.5 | 42.3 ± 2.8 | 42.9 ± 4.0 |
| Red blood cell count, n/mm3 (P = 0.0001) | 4.8 ± 0.5 | 4.9 ± 0.5 | 4.9 ± 0.5 | 5.1 ± 0.5 | 4.9 ± 0.5 | 4.9 ± 0.5 |
| Hb, g/dL (P ≤ 0.0001) | 14.0 ± 1.4 | 14.4 ± 1.4 | 14.6 ± 1.3 | 14.8 ± 1.3 | 14.2 ± 1.1 | 14.5 ± 1.5 |
| White blood cell count, n/mm3 (P ≤ 0.0001) | 6.4 ± 1.7 | 6.7 ± 1.7 | 6.7 ± 1.8 | 6.9 ± 1.7 | 7.7 ± 4.4 | 7.1 ± 1.6 |
| Platelet count, n/mm3 (P ≤ 0.0001) | 270 ± 63 | 266 ± 64 | 267 ± 67 | 259 ± 65 | 263 ± 53 | 250 ± 68 |
| hsCRP, mg/L (P ≤ 0.0001) | 1.7 ± 3.0 | 3.0 ± 4.1 | 2.3 ± 5.5 | 3.6 ± 5.0 | 1.1 ± 0.8 | 4.1 ± 4.4 |
| hCys, µmol/L (P ≤ 0.0001) | 13.3 ± 7.8 | 14.2 ± 9.7 | 14.6 ± 8.6 | 14.6 ± 8.2 | 12.0 ± 3.7 | 14.2 ± 5.5 |
| hsCRP > 5 mg/L (P ≤ 0.0001) | 65 (6.3%) | 102 (13.5%) | 15 (8.2%) | 72 (18.1%) | 0 (0%) | 35 (24.5%) |
| Arterial hypertension# (P ≤ 0.0001) | 140 (13.5%) | 273 (36.2%) | 68 (37.2%) | 241 (60.5%) | 12 (42.9%) | 117 (81.8%) |
Data are means ± SD or counts (percentage). BMI, body mass index; CA.ME.LI.A, CArdiovascular risks, MEtabolic syndrome, LIver and Autoimmune disease; DM, diabetes mellitus; hCys, hyperhomocysteinemia; hsCRP, high-sensitivity C‐reactive protein; IFG, impaired fasting glucose; NBW, normal body weight; NFG, normal fasting glucose; OWO, overweight-obese.
#Arterial hypertension was diagnosed in subjects who presented at least one of the following: systolic arterial pressure ≥140 mmHg, diastolic arterial pressure ≥90 mmHg, or treatment with antihypertensive therapy.