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. 1987 Aug 15;246(1):233–236. doi: 10.1042/bj2460233

Insulin reverses effects of starvation on the activity of pyruvate dehydrogenase kinase in cultured hepatocytes.

D R Marchington 1, A L Kerbey 1, A E Jones 1, P J Randle 1
PMCID: PMC1148263  PMID: 3314865

Abstract

In tissue culture of hepatocytes, insulin (0.1-1 munits/ml for 4 h) reversed completely the effects of starvation of rats to decrease the activity of pyruvate dehydrogenase (PDH) complex and to increase the activities of PDH kinase and PDH kinase activator protein. It had no effect in hepatocytes from fed rats. Significant effects of insulin were detected with 0.01 munit/ml after 4 h, and in 1-2 h with 1 munit/ml.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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