Figure 2.

Identified linked dimensions between fMRI RSFC features and clinical measurements. (A) Top correlations between the symptom score of internalizing-externalizing symptoms dimension and 25 clinical measures. Leading negative correlations include Mood Disorder Questionnaire, Concise Associated Symptoms Tracking, and Altman Self-Rating Mania Scale. Anhedonic depression of Mood and Anxiety Symptoms Questionnaire is the leading positive correlation. The text color of the clinical measures represents the direction of the differences between healthy controls and MDD patients. Red indicates that healthy controls have higher average scores, while blue indicates that patients have higher average scores. (B) Top correlations of depression-protective personality dimension. NEO-Five Factor Inventory subscales (extraversion, conscientiousness, neuroticism) contribute the most. (C, D) Correlation between FC and symptom scores of the two linked dimensions on all patients. Cross-validation permutation results of 1000 repeats are shown in the small panels.