Table A1.

Path-coefficients corresponding to Figure A1.

	Parameter	Estimate	p	Parameter	Estimate	p
eR	Brain volume	0.10±0.02	<0.001	BPF	0.21±0.03	<0.001
	Age	−0.85±0.15	<0.001		−1.14±0.19	<0.001
	WMH load	−0.51±0.10	<0.001		−0.68±0.11	<0.001
mRS	Lesion load	0.24±0.04	<0.001		0.25±0.04	<0.001
	eR	−0.67±0.14	<0.001		−0.48±0.11	<0.001
	Sex	−0.25±0.17	0.15		−0.56±0.15	<0.001
	HTN	−0.04±0.15	0.804		−0.01±0.16	0.956
	DM2	0.39±0.18	0.030		0.44±0.18	0.012
	Smoker	−0.05±0.14	0.712		−0.09±0.14	0.514

(WMH: white matter hyperintensity; eR: effective reserve; HTN: hypertension; DM2: Diabetes Mellitus Type 2; BPF: brain parenchymal fraction)