Figure 2. IC₅₀ and dose-response curves of lead candidates in UM cell lines versus normal fibroblasts.

(A) LogIC₅₀ values of the lead compounds in UM cell lines and normal fibroblasts. The dotted line indicates the highest concentration of drug used (10 μM); hence, for the values above, the IC₅₀ is not determined accurately. n = 4 replicates for each concentration were tested. (B) Concentration-response curves of the top candidates (romidepsin, mivebresib, and quisinostat) for UM cell lines and WS1 fibroblasts. n = 4 per concentrations tested.