Figure 2.

DKN-01 and nivolumab treatment leads to a redistribution of immune cell types in the tumor microenvironment. (A) UMAP embedding of all T cells profiled by scRNAseq labeled by granular subsets. Heatmap showing marker genes for (B) CD4+ and (C) CD8+ T cell subsets. (D) UMAP embedding of myeloid cells profiled by scRNAseq labeled by granular subsets. (E) Heatmap showing marker genes for myeloid cell subsets. Proportion of granular (F) CD4+ T cell, (G) CD8+ T cell and (H) myeloid cell subsets relative to their parent group in pre- and on-treatment biopsies.