Table 3.

Notable putative genes and chromosomal regions studied for schizophrenia gene using linkage and association strategies.

Chromosome No.	Chromosomal region	Significance	Linkage/association studies
1	1p 35–32	*	Garver et al (1998)
	1q 42–1	Translocation	St. Clair et al (1990)
	(1q44)	*	Blouin et al (1998)
	1q 21–3	hSKCa3 gene	Wittekindt et al (1998)
2	(2p15–14)	*	Shaw et al (1998)
	2q21	Balanced translocation	Maziade et al (1993)
3	3p 24	*	Pulver et al (1995)
	3q 13–3	Dopamine receptor D3 gene	Crocq et al (1992); see Jonsson et al (1999) for exhaustive reference
4	4p	*	Asherson et al (1998)
	4q 24–32	*	Kaufmann et al (1998); Kennedy et al (1998); Hovatta et al (1999)
5	5p14–1-13–11	*	Silvermann et al (1996)
	5q	*	Sherrington et al (1988)
	5q21–23	*	Straub et al (1997)
6	6p24–22	* HLA genes Eye tracking dysfunction gene	Moises et al (1995); Straub et al (1995) Nimgaonkar et al (1992, 1995, 1997); Wright et al (1996); summarized in Gibson et al (1999) Arolt et al (1996)
	6q 21–22-3	*	Cao et al (1997)
7	7q21–1-q21–3	*	Blouin et al (1998)
8	8p22–21	*	Pulver et al (1995); Kendler et al (1996)
9	9q34–3	* Dopamineβ hydroxylase gene A subunit of NMDA receptor gene	Riley et al (1997) Meszaros et al (1996) Heresco et al (1999)
10	10p15-q21	*	Faraone et al (1998); Schwab et al (1998); Foroud et al (2000)
11	11p15–5	Dopamine D4 receptor gene	Sommer et al (1993)
	11q 22–23	Dopamine D2 receptor gene	Gejman et al (1994); Shaikh et al (1994); reviewed in Gill et al (1993)
	11q	Translocation	St. Clair et al (1990)
12	-	*	Dawson et al (1995)
13	13q14	5HTR2a (serotonin receptor 2a)	Campbell et al (1997); Erdmann et al (1996)
	13q14–1-q32	*	Riley et al (1998)
	13q32	*	Blouin et al (1998); summarized in Barden and Morissette (1999)
14	-	*	Craddock and Lendon (1999)
15	15q13-q14	* α7 nicotinic cholinergic receptor subunit gene (CHRNA7)	Curtis et al (1999) de Leon et al (1995); summarized in Riley and McGuffin (2000)
16	-	*	Detera-Wadleigh (1999)
17	17q11–2-q12	Serotonin transporter gene (5HTT)	Heils et al (1996); Rao et al (1998)
18	18p	*	Schwab et al (1998); Calzolari et al (1996)
	18q211	*	Williams et al (1999); summarized in Riley and McGuffin (2000)
19	-	*	Parfitt et al (1996); reviewed in Gejman (1999)
20	20p		Hovatta et al (1998)
21	-	*	Byerley et al (1995); reviewed in Gurling (1998)
22	22q13	IL2RB gene COMT gene (catechol-o-methyl transferase) 14–3-3 protein η-chain gene (YWHAH)	Pulver et al (1994) Chen et al (1999) Toyooka et al (1999)
	22q11	Deletion in this region	Basset et al (1998); Basset and Chow (1999); Murphy et al (1998)
	22q12-q13	*	Pulver et al (1994)
	22q (D22S278)	*	Moises et al (1995); summarized in Riley and McGuffin (2000)
X	Pseudoautosomal locus	*	Maier et al (1995); d’Amato (1994)
	Xp11	*	Dann et al (1997)
	Xq27–28	*	DeLisi (1997); summarized in Riley and McGuffin (2000)
Y	Pseudoautosomal region	*	Yamada et al (1982); Crow (1992); summarized in DeLisi (1997)

^*Indicates candidate regions identified by genome scan studies.