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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Mol Psychiatry. 2023 Dec 15;29(6):1895–1905. doi: 10.1038/s41380-023-02355-x

Figure 1. Theoretical mechanistic framework depicting the hypothesized relationship between peripheral and central immune dysregulation and neurophysiology.

Figure 1.

Inflammaging refers to the changes that take place in the innate immune system, distinct from the adaptive immune system, due to the aging process. This typically manifests as a rise in the levels of circulating pro-inflammatory cytokines as individuals age.