Table 3.
Patient background characteristics and outcomes at 5 years based on the EDD scores at the time of Biopsy 2.
| EDD score | 0 | 1 | 2 | 3 | p-Value |
|---|---|---|---|---|---|
| n = 8 | n = 5 | n = 6 | n = 4 | ||
| At 5 years | |||||
| A-5y, no. (%) | 7 (88) | 3 (60) | 2 (33) | 0 (0) | 0.025 |
| B-5y, no. (%) | 7 (88) | 2 (40) | 2 (33) | 0 (0) | 0.025 |
| Cr, mg/dl | 0.65 (0.62–0.70) | 0.72 (0.68–0.88) | 0.64 (0.61–0.67) | 1.61 (1.09–2.78) | 0.021 |
| eGFR (ml/min/1.73 m2) | 78 (72–80) | 65 (53–71) | 77 (71–89) | 45 (21–64) | 0.029 |
| Proteinuria (g/day) | 0.04 (0.03–0.08) | 0.03 (0–0.09) | 0.08 (0.06–0.12) | 0.46 (0.03–1.60) | 0.369 |
| PSL dose (mg/day) | 5 (5–5) | 5 (5–5) | 6 (5–7) | 10 (7–13) | 0.008 |
| At biopsy 2 (2 years) | |||||
| A-2y, no. (%) | 7 (88) | 3 (60) | 2 (33) | 0 (0) | 0.025 |
| B-2y, no. (%) | 6 (75) | 3 (60) | 3 (50) | 0 (0) | 0.104 |
| Cr (mg/dl) | 0.70 (0.65–0.72) | 0.73 (0.66–0.75) | 0.65 (0.57–0.68) | 1.32 (1.05–1.53) | 0.032 |
| eGFR (ml/min/1.73 m2) | 79 (70–81) | 66 (59–80) | 84 (69–91) | 43 (34–57) | 0.108 |
| Proteinuria (g/day) | 0.03 (0.01–0.06) | 0.05 (0.03–0.05) | 0.06 (0.04–0.15) | 0.62 (0.34–1.08) | 0.178 |
| PSL dose (mg/day) | 5 (5–5) | 5 (5–5) | 6 (5–7) | 11 (10–12) | 0.004 |
| Baseline | |||||
| Age, years | 43 (28–52) | 46 (36–63) | 47 (28–53) | 54 (38–66) | 0.871 |
| Female sex, no. (%) | 8 (100) | 4 (80) | 6 (100) | 2 (50) | 0.068 |
| SLEDAI-2K scores | 21 (12–24) | 21 (18–27) | 21.5 (16–24) | 23.5 (21–26) | 0.869 |
| Cr (mg/dl) | 0.69 (0.58–0.70) | 0.70 (0.61–0.77) | 0.59 (0.46–0.68) | 1.35 (1.12–1.73) | 0.023 |
| eGFR (ml/min/1.73 m2) | 82 (77–86) | 71 (58–88) | 94 (77–108) | 37 (26–53) | 0.065 |
| Proteinuria (g/day) | 2.3 (0.60–3.9) | 1.7 (0.84–3.6) | 4.2 (2.5–5.5) | 4.0 (2.1–7.2) | 0.327 |
Data are shown as the median (IQR) or the number of patients (percentage).
A-5y, “A” goal at 5 years defined as SLEDAI-2K = 0 and PSL ⩽5 mg/day; B-5y, “B” goal at 5 years defined as proteinuria ⩽0.2 g/day, normal serum Cr levels, and PSL ⩽5 mg/day; A-2y, “A” goal at 2 years; B-2y, “B” goal at 2 years.
EDD score, electron-dense deposit score; Cr, creatinine; eGFR, estimated glomerular filtration rate; IQR, interquartile range; PSL, prednisolone; SLEDAI-2K, Systemic Lupus Erythematosus Disease Activity Index 2000.