TABLE 3.
Univariate regression analysis demonstrating unadjusted association between demographic/clinical variables and Skindex‐2 scores. a
| Variable | Univariate analysis Skindex‐29 symptoms | Univariate analysis Skindex‐29 emotions | Univariate analysis Skindex‐29 functioning | Univariate analysis Skindex‐29 total | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) Skindex symptoms | Coefficient (95% CI) | p‐value | Mean (SD) Skindex emotions | Coefficient (95% CI) | p‐value | Mean (SD) Skindex functioning | Coefficient (95% CI) | p‐value | Mean Skindex‐29 total | Coefficient (95% CI) | p‐value | |
| Age (years) b | ||||||||||||
| 20–29 | 27.75 (25.89) | 2.812 (−1.23 to 6.85) | 0.170 | 34.42 (28.94) | −1.314 (−6.29 to 3.66) | 0.602 | 13.62 (17.44) | 1.000 (−3.35 to 5.35) | 0.649 | 75.79 (64.71) | 2.210 (−9.85–14.26) | 0.717 |
| 30–39 | 30.12 (23.88) | 52.30 (27.65) | 30.87 (26.35) | 113.28 (66.61) | ||||||||
| 40–49 | 34.62 (20.72) | 44.23 (28.76) | 26.01 (27.07 | 104.86 (71.23) | ||||||||
| 50–59 | 37.50 (25.00) | 31.12 (26.99) | 18.06 (23.29) | 86.68 (69.14) | ||||||||
| 60+ | 37.50 (32.03) | 44.43 (37.67) | 28.75 (32.64) | 110.88 (98.25) | ||||||||
| Gender | ||||||||||||
| Male | 22.99 (19.67) | Ref | 0.005 | 35.53 (29.56) | Ref | 0.040 | 18.52 (22.21) | Ref | 0.076 | 77.03 (61.55) | Ref | 0.014 |
| Female | 37.34 (25.10) | 14.352 (4.35–24.36) | 48.60 (29.11) | 13.073 (−0.63–25.52) | 28.89 (27.51) | 9.958 (−1.07 to 20.98) | 114.83 (73.77) | 37.80 | ||||
| Facial cNFs | ||||||||||||
| Absent | 26.88 (21.82) | Ref | 0.051 | 40.99 (28.64) | Ref | 0.317 | 18.80 (22.59) | Ref | 0.027 | 86.67 (62.05) | Ref | 0.065 |
| Present | 36.71 (25.31) | 9.831 (−0.03 to 19.6) | 47.16 (30.26) | 6.170 (−5.99 to 18.33) | 30.21 (27.61) | 11.88 (1.41–22.36) | 114.07 (75.99) | 27.40 (−1.72 to 56.52) | ||||
| No. of cNFs b | ||||||||||||
| <20 | 26.79 (21.33) | 5.934 (1.57–10.29) | 0.008 | 27.50 (24.07) | 8.273 (3.04–13.51) | 0.002 | 11.45 (17.67) | 8.314 (3.85–12.78) | 0.000 | 65.74 (47.38) | 22.35 (9.82–34.88) | 0.001 |
| 20–99 | 26.73 (23.82) | 43.53 (30.47) | 23.77 (26.50) | 94.04 (75.07) | ||||||||
| 100–500 | 30.16 (27.40) | 45.89 (26.85) | 24.30 (25.10) | 100.34 (66.96) | ||||||||
| >500 | 43.20 (23.82) | 55.50 (31.39) | 38.28 (27.37) | 136.98 (76.10) | ||||||||
| Visibility b | ||||||||||||
| 1 | 27.04 (21.65) | 9.064 (3.18–14.94) | 0.003 | 38.16 (28.14) | 7.271 (−0.11–14.65) | 0.053 | 19.51 (23.81) | 8.693 (2.28–15.10) | 0.008 | 84.72 (63.73) | 25.15 (7.65–42.66) | 0.005 |
| 2 | 32.62 (22.68) | 49.77 (29.06) | 27.09 (24.53) | 109.48 (66.78) | ||||||||
| 3 | 46.26 (28.13) | 51.35 (32.63) | 37.54 (30.67) | 135.15 (86.48) | ||||||||
| Severity b | ||||||||||||
| 1 | 19.64 (23.53) | 10.275 (3.07–14.67) | 0.003 | 31.75 (31.47) | 4.595 (−2.78 to 11.98) | 0.219 | 15.83 (22.78) | 7.135 (0.17–13.56) | 0.030 | 67.23 (69.36) | 20.43 (2.83–38.03) | 0.023 |
| 2 | 30.03 (20.87) | 44.55 (27.49) | 22.86 (23.91) | 97.45 (62.83) | ||||||||
| 3 | 32.33 (24.65) | 44.51 (31.04) | 27.44 (27.78) | 104.29 (75.52) | ||||||||
| 4 | 54.64 (26.46) | 51.50 (33.90) | 39.78 (31.69) | 145.92 (88.20) | ||||||||
| Itch | ||||||||||||
| No | 25.86 (23.66) | Ref | 0.000 | 40.15 (31.61) | 10.164 (−1.68 to 22.01) | 0.092 | 21.69 (23.83) | Ref | 0.070 | 87.70 (70.29) | Ref | 0.013 |
| Yes | 42.26 (22.20) | 16.839 (7.59–26.09) | 50.31 (26.18) | 30.94 (28.75) | 9.617 (−0.78 to 29.92) | 123.51 (69.89) | 35.81 (7.62–64.01) | |||||
Abbreviations: CI, confidence interval; cNFs, cutaneous neurofibromas; DLQI, Dermatology Life Quality Index; HADS, Hospital Anxiety and Depression Scale; NF1‐AdQOL, Neurofibromatosis 1‐adult quality‐of‐life questionnaire; SD, standard deviation.
The univariate regression analysis for all surveys did not fit in one table. See Tables S3a and S4b for univariate regression analysis between demographic/clinical variables and NF1‐AdQOL, DLQI, and HADS.
Variable fitted as continuous variable in regression modeling. Unit of measurement is per 10 year increase for age, and per 1 unit increase for number of cNFs, visibility, and severity score.