. 2024 Oct 17;24:242. doi: 10.1186/s12874-024-02363-7

Table 4.

Boundary sets ${l_{1}, u_{1}, d_{1}, d_{2}}$ and theoretical global performance characteristics for GSD, DR-GSD, and RR-GSD for the example in Mehta and Pocock [12], where $I_{1} = 0.29$ and $I_{Δ_{t}} = 0.3$

Method	$(l_{1}, u_{1})$	$d_{1}$	$d_{2}$	P(futility)	$P (r e j e c t a t i n t e r i m)$	Power	$E_{δ} [N]$
Fixed design	NA	NA	1.960	NA	NA	0.80	690
GSD	(0.259, 2.322)	NA	2.119	0.106	0.208	0.722	601.286
DR-GSD	(0.259, 2.322)	1.584	2.119	0.089	0.224	0.739	601.286
RR-GSD	$(- 0.164, 1.815)$	1.960	2.043	0.098	0.329	0.737	569.222

Abbreviations: GSD Group-sequential design, DR-GSD Delayed response group-sequential design, RR-GSD Repeated rejection group-sequential design