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. 1987 Oct 15;247(2):467–473. doi: 10.1042/bj2470467

The cross-linking of tyrosine residues in apo-ovotransferrin by treatment with periodate anions.

J J Hsuan 1
PMCID: PMC1148431  PMID: 2827629

Abstract

The iron-binding ability of apotransferrins is rapidly abolished in the reaction with periodate anions, which destroys 4 mol of tyrosine per mol of protein. Treatment of ovotransferrin with cyanogen bromide and tryptic digestion of the glycopeptide fragment demonstrated the existence of an intramolecular cross-link in the C-terminal domain of the oxidized protein. The cross-linked residues were identified as Tyr-421 and Tyr-524 and the product is similar in structure to 3,3'-dityrosine.

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Selected References

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