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. 2024 Oct 16;25:355. doi: 10.1186/s12882-024-03803-8

Table 1.

Clinicopathological characteristics according to arteriolar wall thickening

Arteriolar wall thickening (+) Arteriolar wall thickening (-) p-value
(n = 76) (n = 62)
Clinical Information
Gender (%)
Male 37(48.7) 33(53.2) 0.6
Female 39(51.3) 29(46.8)
Age (mean) 19–74 (46) 18–74 (35) 0.000006*
Hypertension (%) 34(44.7) 16(25.8) 0.03*
DM (%) 5(6.6) 0(0) 0.06
Systolic BP 98–210 (128) 78–172 (124.8) 0.28
mm Hg (mean)
Diastolic BP 46–120 (76.7) 46–90 (72.1) 0.03*
mm Hg (mean)
eGFR 9-128 (65.7) 15–155 (97.2) 0.00000005*
mL/min/1.73m2 (mean)
UPCR 0.09–13.12 (2.17) 0.05–5.58 (1.07) 0.0009*
g/gCr (mean)
BUN 6-64.1 (20.1) 5.8–96 (16.6) 0.08
mg/dL (mean)
Scr 0.5–5.12 (1.4) 0.49–5.49 (1.0) 0.004*
µmol/L (mean)
Uric acid 3.1–11.4 (6.8) 3.5–11.3 (6.2) 0.055
µmol/L (mean)
Hemoglobin 8.4–17.1 (13.1) 4–19 (13.7) 0.1
g/L (mean)
Platelet count 24–603 (254.6) 157–463 (265.6) 0.44
×109 /L (mean)
Albumin 1.9–5.1 (4.1) 2.7–5.4 (4.4) 0.003*
g/L (mean)
Total cholesterol 120–360 (207) 101–243 (171) 0.000005*
mmol/L (mean)
Medications
RAAS blockers (%) 47(61.8) 15(24.2) 0.00001*
Steroids and other immunosuppressants (%) 1(1.3) 1(1.6) 1
Oxford classification score
M0/1(%) 70(92.1)/6(7.9) 56(90.3)/6(9.3) 0.77
E0/1(%) 61(80.3)/15(19.7) 56(90.3)/6(9.7) 0.15
S0/1(%) 24(31.6)/52(68.4) 31(50)/31(50) 0.036*
T0/1/2(%) 35(46.1)/19(25)/22(28.9) 56(90.3)/4(6.5)/2(3.2) 0.00000007*
C0/C1/C2(%) 51(67.1)/23(30.3)/2(2.6) 42(67.7)/20(32.3)/0(0) 0.63
Pathological Features
Global glomerulosclerosis % (mean) 0-96.3 (28.2) 0-63.6 (9.9) 0.0000009*
Haas I/II/III/IV/V (%) 17(22.4)/16(21.1)/28(36.8)/ 25(40.3)/14(22.6)/21(33.9)/ 0.01
7(9.2)/8(10.5) 2(3.2)/0(0)
IFTA 0/1/2/3(%) 14(18.4)/23(30.3)/18(23.7)/ 39(62.9)/15(24.2)/5(8.1)/ 0.0000001*
21(27.6) 3(4.8)
I IFTA 0/1/2/3(%) 17(22.4)/23(30.3)/24(31.6)/ 41(66.1)/15(24.2)/3(4.8)/ 0.0000002*
12(15.8) 3(4.8)
Ti 0/1/2/3(%) 18(23.7)/32(42.1)/11(14.5)/ 42(67.7)/16(25.8)/2(3.2)/ 0.0000006*
15(19.7) 2(3.2)

BP, blood pressure; eGFR, estimated glomerular filtration rate; BSA, body surface area; UPCR, urine protein-to-creatinine ratio; BUN, blood urea nitrogen; Scr, serum creatinine; RAAS renin-angiotensin-aldosterone system; IFTA, interstitial fibrosis and tubular atrophy. I IFTA, inflammatory IFTA; Oxford classification: M, mesangial hypercellularity; S, segmental sclerosis; T, interstitial fibrosis/tubular atrophy; C, and crescents.