Table 1.
Arteriolar wall thickening (+) | Arteriolar wall thickening (-) | p-value | ||||
---|---|---|---|---|---|---|
(n = 76) | (n = 62) | |||||
Clinical Information | ||||||
Gender (%) | ||||||
Male | 37(48.7) | 33(53.2) | 0.6 | |||
Female | 39(51.3) | 29(46.8) | ||||
Age (mean) | 19–74 (46) | 18–74 (35) | 0.000006* | |||
Hypertension (%) | 34(44.7) | 16(25.8) | 0.03* | |||
DM (%) | 5(6.6) | 0(0) | 0.06 | |||
Systolic BP | 98–210 (128) | 78–172 (124.8) | 0.28 | |||
mm Hg (mean) | ||||||
Diastolic BP | 46–120 (76.7) | 46–90 (72.1) | 0.03* | |||
mm Hg (mean) | ||||||
eGFR | 9-128 (65.7) | 15–155 (97.2) | 0.00000005* | |||
mL/min/1.73m2 (mean) | ||||||
UPCR | 0.09–13.12 (2.17) | 0.05–5.58 (1.07) | 0.0009* | |||
g/gCr (mean) | ||||||
BUN | 6-64.1 (20.1) | 5.8–96 (16.6) | 0.08 | |||
mg/dL (mean) | ||||||
Scr | 0.5–5.12 (1.4) | 0.49–5.49 (1.0) | 0.004* | |||
µmol/L (mean) | ||||||
Uric acid | 3.1–11.4 (6.8) | 3.5–11.3 (6.2) | 0.055 | |||
µmol/L (mean) | ||||||
Hemoglobin | 8.4–17.1 (13.1) | 4–19 (13.7) | 0.1 | |||
g/L (mean) | ||||||
Platelet count | 24–603 (254.6) | 157–463 (265.6) | 0.44 | |||
×109 /L (mean) | ||||||
Albumin | 1.9–5.1 (4.1) | 2.7–5.4 (4.4) | 0.003* | |||
g/L (mean) | ||||||
Total cholesterol | 120–360 (207) | 101–243 (171) | 0.000005* | |||
mmol/L (mean) | ||||||
Medications | ||||||
RAAS blockers (%) | 47(61.8) | 15(24.2) | 0.00001* | |||
Steroids and other immunosuppressants (%) | 1(1.3) | 1(1.6) | 1 | |||
Oxford classification score | ||||||
M0/1(%) | 70(92.1)/6(7.9) | 56(90.3)/6(9.3) | 0.77 | |||
E0/1(%) | 61(80.3)/15(19.7) | 56(90.3)/6(9.7) | 0.15 | |||
S0/1(%) | 24(31.6)/52(68.4) | 31(50)/31(50) | 0.036* | |||
T0/1/2(%) | 35(46.1)/19(25)/22(28.9) | 56(90.3)/4(6.5)/2(3.2) | 0.00000007* | |||
C0/C1/C2(%) | 51(67.1)/23(30.3)/2(2.6) | 42(67.7)/20(32.3)/0(0) | 0.63 | |||
Pathological Features | ||||||
Global glomerulosclerosis % (mean) | 0-96.3 (28.2) | 0-63.6 (9.9) | 0.0000009* | |||
Haas I/II/III/IV/V (%) | 17(22.4)/16(21.1)/28(36.8)/ | 25(40.3)/14(22.6)/21(33.9)/ | 0.01 | |||
7(9.2)/8(10.5) | 2(3.2)/0(0) | |||||
IFTA 0/1/2/3(%) | 14(18.4)/23(30.3)/18(23.7)/ | 39(62.9)/15(24.2)/5(8.1)/ | 0.0000001* | |||
21(27.6) | 3(4.8) | |||||
I IFTA 0/1/2/3(%) | 17(22.4)/23(30.3)/24(31.6)/ | 41(66.1)/15(24.2)/3(4.8)/ | 0.0000002* | |||
12(15.8) | 3(4.8) | |||||
Ti 0/1/2/3(%) | 18(23.7)/32(42.1)/11(14.5)/ | 42(67.7)/16(25.8)/2(3.2)/ | 0.0000006* | |||
15(19.7) | 2(3.2) |
BP, blood pressure; eGFR, estimated glomerular filtration rate; BSA, body surface area; UPCR, urine protein-to-creatinine ratio; BUN, blood urea nitrogen; Scr, serum creatinine; RAAS renin-angiotensin-aldosterone system; IFTA, interstitial fibrosis and tubular atrophy. I IFTA, inflammatory IFTA; Oxford classification: M, mesangial hypercellularity; S, segmental sclerosis; T, interstitial fibrosis/tubular atrophy; C, and crescents.