Table 2.
Clinicopathological characteristics according to fibrous intimal thickening
| Intimal thickening (+) | Intimal thickening (-) | p-value | |
|---|---|---|---|
| (n = 47) | (n = 86) | ||
| Clinical Information | |||
| Gender (%) | |||
| Male | 21(44.7) | 47(54.7) | 0.28 |
| Female | 26(55.3) | 39(45.3) | |
| Age (mean) | 24–74 (49) | 18–73 (37) | 0.000004* |
| Hypertension (%) | 21(44.7) | 27(31.4) | 0.14 |
| DM (%) | 1(2.1) | 3(3.5) | 1 |
| Systolic BP | 100–210 (130.1) | 78–172 (125.2) | 0.11 |
| mm Hg (mean) | |||
| Diastolic BP | 55–110 (77.1) | 46–120 (73.7) | 0.12 |
| mm Hg (mean) | |||
| eGFR | 9-120 (64.6) | 9-141 (88) | 0.0002* |
| mL/min/1.73m2 (mean) | |||
| UPCR | 0.2–8.18 (2.19) | 0.05–9.81 (1.29) | 0.003* |
| g/gCr (mean) | |||
| BUN | 10.3–64.1 (20.4) | 6–96 (17.5) | 0.2 |
| mg/dL (mean) | |||
| Scr | 0.5–4.92 (1.37) | 0.55–5.49 (1.18) | 0.2 |
| µmol/L (mean) | |||
| Uric acid | 4.4–11.4 (7) | 3.1–11.3 (6.3) | 0.06 |
| µmol/L (mean) | |||
| Hemoglobin | 8.7–17.1 (12.9) | 4–19 (13.6) | 0.07 |
| g/L (mean) | |||
| Platelet count | 149–603 (273.2) | 24–464 (250.3) | 0.13 |
| ×109 /L (mean) | |||
| Albumin | 2.1-5 (4) | 2.7–5.4 (4.3) | 0.006* |
| g/L (mean) | |||
| Total cholesterol | 138–360 (207) | 101–328 (182) | 0.003* |
| mmol/L (mean) | |||
| Medications | |||
| RAAS blockers (%) | 24(51.1) | 38(44.2) | 0.47 |
| Steroids and immunosuppressants (%) | 1(2.1) | 1(1.2) | 1 |
| Oxford classification score | |||
| M0/1(%) | 42(89.4)/5(10.6) | 80(93)/6(7) | 0.52 |
| E0/1(%) | 40(85.1)/7(14.9) | 73(84.9)/13(15.1) | 1 |
| S0/1(%) | 16(34)/31(66) | 36(41.9)/50(58.1) | 0.46 |
| T0/1/2(%) | 22(46.8)/11(23.4)/14(29.8) | 67(77.9)/10(11.6)/9(10.5) | 0.001* |
| C0/C1/C2(%) | 29(61.7)/16(34)/2(4.3) | 59(68.6)/27(31.4)/0(0) | 0.17 |
| Pathological Features | |||
| Global glomerulosclerosis, % (mean) | 0-96.3 (26.3) | 0–90 (16.2) | 0.01* |
| Haas I/II/III/IV/V(%) | 10(21.3)/12(25.5)/18(38.3)/ | 30(34.9)/16(18.6)/31(36)/ | 0.47 |
| 3(6.4)/4(8.5) | 5(5.8)/4(4.7) | ||
| IFTA 0/1/2/3(%) | 8(17)/15(31.9)/9(19.1)/ | 44(51.2)/22(25.6)/12(14)/ | 0.0002* |
| 15(31.9) | 8(9.3) | ||
| I IFTA 0/1/2/3(%) | 13(27.7)/16(34)/10(21.3)/ | 43(50)/21(24.4)/15(17.4)/ | 0.066 |
| 8(17) | 7(8.1) | ||
| Ti 0/1/2/3(%) | 13(27.7)/17(36.2)/6(12.7)/11(23.4) | 45(52.3)/30(34.9)/5(5.8)/ | 0.006* |
| 11(23.4) | 6(7) |
BP, blood pressure; eGFR, estimated glomerular filtration rate; BSA, body surface area; UPCR, urine protein-to-creatinine ratio; BUN, blood urea nitrogen; Scr, serum creatinine; RAAS renin-angiotensin-aldosterone system; IFTA, interstitial fibrosis and tubular atrophy. I IFTA, inflammatory IFTA; Oxford classification: M, mesangial hypercellularity; S, segmental sclerosis; T, interstitial fibrosis/tubular atrophy; C, and crescents.