Fig. 1.

Expression of selected synaptic proteins and their associated proteins. Panels (a) and (b), are plots for children and adults, respectively, of −log₁₀ (adjusted P-value) vs. log₂ (fold-change) for all proteins, computed for adjusted P-value of linear models of protein concentration based on peptide quantitation. Synaptic and associated proteins are labeled when above the threshold of significance. Panels (c) and (d) represent heatmaps of quantitations for synaptic and associated proteins. Quantities are centered and standard-scaled for each protein. Proteins are hierarchically clustered using Pearson correlation as the distance metric (longer lines perpendicular to the axis indicate lower correlation) and the “ward.D2” agglomerative clustering method. Undetected or unquantitated proteins are marked “NA.”