Thermodynamic data for binary Q7·peptide complexes.

Host	Peptide	K a (M−1)	ΔH (kcal mol−1)	-TΔS (kcal mol−1)
Q7a	H-Phe-Ala-OH	7.9 × 105	−7.3	−0.7
Q7a	H-dPhe-Ala-OH	1.3 × 106	−7.8	−0.6
Q7a	H-Phe-Pro-OH	2.9 × 104	−5.9	−0.2
Q7a	H-Phe-dPro-OH	5.0 × 104	−6.5	0.1
Q7a	H-Phe-Phe- NH2	5.3 × 106	−8.8	−0.4
Q7a	H-dPhe-Phe- NH2	1.3 × 106	−6.9	−1.4
Q7a	H-Phe-Leu-NH2	1.4 × 107	−8.7	−1.1
Q7a	H-Phe-dLeu-NH2	1.7 × 106	−5.8	−2.7
Q7b	H-Phe-Gly-OH	3.0 × 107	−11.3	1.1
Q7b	H-Gly-Phe-OH	1.3 × 103	−7.2	2.9
Q7b	H-Tyr-Gly-OH	3.6 × 106	−10.6	1.6
Q7b	H-Gly-Tyr-OH	2.0 × 102	−5.5	2.4
Q7b	H-Trp-Gly-OH	5.6 × 105	−10.7	2.8
Q7b	H-Gly-Trp-OH	2.8 × 102	−4.3	1.0
Q7b	H-Phe-Ala-OH	1.9 × 107	−11.8	1.9
Q7b	H-Ala-Phe-OH	1.3 × 103	−8.3	4.0
Q7c	H-Phe-Gly-OH	1.7 × 106	−7.7	−0.9
Q7c	H-Phe-Ala-OH	7.9 × 105	−7.3	−0.7
Q7c	H-Phe-Gly-NH2	3.7 × 106	−7.4	−1.6
Q7c	H-Gly-Phe-NH2	4.4 × 104	−7.3	1.0
Q7c	H-Phe-Ala-NH2	8.1 × 106	−9.9	0.5
Q7c	H-Ala-Phe-NH2	4.5 × 104	−7.7	1.4
Q7c	H-Tyr-Gly-NH2	1.1 × 107	−10.2	0.6
Q7c	H-Gly-Tyr-NH2	7.5 × 104	−9.4	2.7
Q7d	H-Phe-Gly-Gly-OH	2.8 × 106	−17.5	8.7
Q7d	H-Gly-Phe-Gly-OH	2.2 × 104	−9.3	3.3
Q7d	H-Gly-Tyr-Gly-OH	2.7 × 103	−2.2	−2.5
Q7e	H-Phe-Gly-Gly-NH2	3.2 × 106	−13.4	4.4
Q7e	H-Gly-Phe-Gly-NH2	2.3 × 105	−9.8	2.4
Q7e	H-tBuPhe-Gly-Gly-NH2	4.8 × 106	−16.2	7.1
Q7e	H-AmPhe-Gly-Gly-NH2	1.1 × 109	−14.2	1.8
Q7e	H-Gly-AmPhe-Gly-NH2	2.0 × 106	−8.2	−0.5
Q7f	H-AmPhe-Gly-Asn-Gln-NH2	2.0 × 107	−16.9	6.8
Q7f	H-Phe-Gly-Asn-Gln-NH2	7.1 × 106	−15.6	6.1
Q7f	H-AmPhe-Val-Asn-Gln-NH2	1.3 × 107	−15.7	6.0
Q7f	H-Phe-Val-Asn-Gln-NH2	4.0 × 106	−14.5	5.3
Q7g	H-Phe-Gly-Gly-Gly-Cys	1.2 × 107	−13.8	4.15
Q7h	H-Thr-Gly-Ala-Phe-Met-NH2	1.3 × 104	nrn	nr
Q7h	H-Thr-Gly-dAla-Phe-Met-NH2	2.6 × 104	nr	nr
Q7h	H-Thr-Gly-Ala-Phe-Leu-NH2	3.5 × 103	nr	nr
Q7h	H-Thr-Gly-Ser-Phe-Met-NH2	1.9 × 104	nr	nr
Q7h	H-Thr-Gly-Gly-Phe-Met-NH2	1.4 × 104	nr	nr
Q7h	H-Thr-Gly-Ala-Phe-Leu-OH	1.8 × 103	nr	nr
Q7h	H-Phe-Met-NH2	1.5 × 107	nr	nr
Q7h	H-Phe-Leu-NH2	2.7 × 107	nr	nr
Q7h	H-Phe-Leu-OH	2.1 × 106	nr	nr
Q7i	H-Thr-Gly-Ala-Phe-Met-NH2	3.2 × 103	nr	nr
Q7i	H-Thr-Gly-Ala-Phe-Leu-NH2	1.4 × 104	nr	nr
Q7i	H-Thr-Gly-Ala-Phe-Leu-OH	2.4 × 103	nr	nr
Q7i	H-Phe-Met-NH2	2.6 × 107	nr	nr
Q7i	H-Phe-Leu-NH2	1.4 × 107	nr	nr
Q7i	H-Phe-Leu-OH	2.1 × 106	nr	nr
Q7j	H-Phe-Met-NH2	1.4 × 107	−22.7	12.9
Q7j	H-Tyr-Met-NH2	6.4 × 105	−20.0	12.1
Q7j	H-Trp-Met-Gly-NH2	2.3 × 105	−20.1	12.7
Q7j	H-AmPhe-Met-NH2	5.3 × 108	−10.5	−1.8
Q7k	H-His-Phe-OH	5.0 × 102	nr	nr
Q7k	H-His-Leu-OH	5.0 × 102	nr	nr
Q7k	H-His-Tyr-OH	1.1 × 102	nr	nr
Q7k	H-Gly-His-OH	3.3 × 102	nr	nr
Q7k	H-Leu-His-OH	2.2 × 104	nr	nr
Q7k	H-Tyr-His-OH	1.2 × 105	nr	nr
Q7k	H-Gly-Gly-His-OH	<102	nr	nr
Q7l	H-Pro-Leu-Ile-Tyr-Leu-Arg-Leu-Leu-Arg-Gly-Gln-Phe-OH	ndm	nr	nr
Q7l	H-Arg7-OH	nd	nr	nr
Q7l	H-Leu-Arg-Arg-Trp-Ser-Leu-Gly-OH	nd	nr	nr
Q7l	H-Leu-Arg-Arg-Trp-pSer-Leu-Gly-OH	nd	nr	nr
Q7l	H-Trp-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH	4.1 × 104	nr	nr
Q7l	H-Trp-Lys-Arg-pThr-Leu-Arg-Arg-Leu-OH	4.1 × 104	nr	nr
Q7l	H-Phe-Arg7-OH	2.9 × 107	nr	nr

^a0.1 M NaCl, 298 K, dPhe is the D-isomer.⁶⁶

^bPure water, 298 K.⁶⁷

^c0.1 M NaCl, 298 K.⁶⁷

^d10 mM sodium phosphate, pH 7.0, 300 K.⁶⁸

^e10 mM sodium phosphate, pH 7.0, 300 K, tBuPhe is 4-tert-butylphenylalanine, AmPhe is 4-aminomethylphenylalanine.⁶⁹

^f10 mM sodium phosphate, pH 7.0, 300 K.⁷⁰

^gPure water, 298 K.⁵²

^h10 mM ammonium phosphate, pH 7.2, 310 K.⁷¹

ⁱ10 mM sodium phosphate, pH 7.0, 298 K.⁷²

^j10 mM ammonium phosphate, pH 7.2, 300 K.⁷³

^k50 mM sodium phosphate, pH 4.74, 298 K.⁵⁴

^l10 mM ammonium phosphate, pH 7.0, temperature not reported, pSer is phosphoserine, pThr is phosphothreonine.⁴⁴

^mNot detected.

ⁿNot reported. Putative binding sites are in bold.