Table 3.

Adjusted Difference in Log₁₀-Transformed Hair Cortisol per Quartile Increase in Gestational or Childhood Phthalate Metabolite Mixture, Health Outcomes and Measures of the Environment Study, Cincinnati, Ohio, 2003–2019^a

	Gestation		Childhood
	All Children		All Children (n = 205)		Girls (n = 116)		Boys (n = 89)		NHB (n = 68)		NHW (n = 125)
Effect Size and Weights	Negative	Positive	Negative	Positive	Negative	Positive	Negative	Positive	Negative	Positive	Negative	Positive
Scaled effect size	−0.08	0.08	−0.07	0.20	−0.08	0.17	−0.21	0.37	−0.21	0.48	−0.15	0.18
Weights
DEHPb		0.28		0.09	0.46			0.28		0.06		0.11
MBzP	0.68			0.25		0.26		0.03		0.36		0.25
MCNP	–c	–c		0.04		0.03	0.29		0.04		0.41
MCOP	–c	–c	0.08		0.11			0.07		0.23		0.15
MCPP	0.14			0.01		0.04		0.18	0.43			0.34
MEP		0.25		0.34		0.45		0.21		0.09		0.02
MiBP	0.19			0.27		0.23		0.24		0.27		0.13
MnBP		0.47	0.92		0.44		0.71		0.53		0.59

Abbreviations: DEHP, di(2-ethylhexyl) phthalate; MBzP, monobenzyl phthalate; MCNP, monocarboxynonyl phthalate; MCOP, monocarboxyoctyl phthalate; MCPP, mono(3-carboxypropyl) phthalate; MEP, monoethyl phthalate; MiBP, monoisobutyl phthalate; MnBP, mono-n-butyl phthalate; NHB, non-Hispanic Black; NHW, non-Hispanic White.

^a Adjusted quantile-based g-computation model includes child sex (categorical), child race (categorical), age at hair collection (continuous), maternal education (categorical), and parity (categorical); n = 205. Weights in each direction sum to approximately 1.0 and represent the proportion that each metabolite contributes to the positive or negative scaled effect.

^b Summary DEHP measure = sum of the molar mass of mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP), and mono-2-ethyl-5-carboxypentyl phthalate (MECPP).

^c Phthalate metabolites not quantified in urine samples.