Table 4.

Adjusted Difference in Log₁₀-Transformed Hair Cortisol per Quartile Increase in Gestational or Childhood Per-/Polyfluoroalkyl Substances Mixture, Health Outcomes and Measures of the Environment Study, Cincinnati, Ohio, 2003–2019^a

	Gestation		Childhood
	All Children		All Children		Girls		Boys		NHB		NHW
Effect Size and Weights	Negative	Positive	Negative	Positive	Negative	Positive	Negative	Positive	Negative	Positive	Negative	Positive
Scaled effect size	−0.04	0.05	−0.13	0.08	−0.06	0.10	−0.21	0.12	−0.1	0.04	−0.13	0.12
Weights
PFOA	1.00		0.47		0.35		0.43			0.72	0.57
PFOS		0.26	0.43		0.65		0.57		0.74		0.16
PFNA		0.11		1.00		0.84		0.95	0.26			1.00
PFHxS		0.63	0.10			0.16		0.05		0.28	0.27

Abbreviations: NHB, non-Hispanic Black; NHW, non-Hispanic White; PFHxS, perfluorohexane sulfonate; PFNA, perfluorononanoate; PFOA, perfluorooctanoate; PFOS, perfluorooctane sulfonate.

^a Adjusted quantile-based g-computation model includes child sex (categorical), child race (categorical), age at hair collection (continuous), maternal education (categorical), parity (categorical), and breastfeeding duration (continuous); gestation n = 175, childhood n = 174. Weights in each direction sum to approximately 1.0 and represent the proportion that each metabolite contributes to the positive or negative scaled effect.