Table 3.

Multivariate Cox analyses for progression-free survival and overall survival in subgroups according to post-1st transplantation treatment (tandem transplantation vs. maintenance therapy) according to risk factors at diagnosis.

Risk factors at diagnosis	Category	PFS			OS
		HR	95% CI	p	HR	95% CI	p
ISS-1	Tandem	1.04	0.67–1.61	0.858	1.58	0.92–2.71	0.101
	Maintenance	0.65	0.44–0.94	0.023	0.69	0.41–1.11	0.172
ISS-2	Tandem	1.04	0.70–1.53	0.861	1.24	0.76–2.03	0.391
	Maintenance	0.78	0.54–1.13	0.188	0.67	0.41–1.11	0.122
ISS-3	Tandem	0.53	0.34–0.81	0.004	0.63	0.38–1.06	0.079
	Maintenance	0.72	0.50–1.05	0.086	0.66	0.41–1.07	0.089
Standard risk (FISH)	Tandem	0.87	0.61–1.22	0.414	0.93	0.59–1.45	0.741
	Maintenance	0.72	0.55–0.94	0.015	0.64	0.44–0.93	0.020
High risk (FISH)	Tandem	0.54	0.29–0.99	0.046	0.69	0.33–1.44	0.323
	Maintenance	0.73	0.41–1.32	0.301	0.58	0.29–1.18	0.136
Normal karyotype	Tandem	0.97	0.70–1.34	0.842	1.23	0.82–1.86	0.315
	Maintenance	0.74	0.56–0.98	0.038	0.74	0.50–1.09	0.132
Abnormal karyotype	Tandem	0.79	0.52–1.21	0.281	1.05	0.64–1.72	0.850
	Maintenance	0.95	0.64–1.40	0.799	0.80	0.49–1.32	0.383
Complex karyotype	Tandem	0.82	0.52–1.27	0.370	1.06	0.62–1.81	0.822
	Maintenance	0.85	0.55–1.31	0.461	0.71	0.41–1.23	0.224
Normal LDH	Tandem	0.73	0.51–1.03	0.074	1.02	0.66–1.56	0.938
	Maintenance	0.88	0.68–1.14	0.340	0.80	0.56–1.14	0.220
Elevated LDH	Tandem	0.68	0.45–1.02	0.061	0.89	0.55–1.44	0.629
	Maintenance	0.38	0.24–0.61	<  0.001	0.51	0.29–0.89	0.018

CI, confidence interval; HR, hazard ratio; PFS, progression-free survival; OS, overall survival; ISS, International Staging System; FISH, fluorescence in situ hybridisation; LDH, lactate dehydrogenase.