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. 1987 Nov 1;247(3):789–792. doi: 10.1042/bj2470789

The effects of recombinant tumour necrosis factor (cachectin) on metabolism in isolated rat adipocyte, hepatocyte and muscle preparations.

A M Rofe 1, R A Conyers 1, R Bais 1, J R Gamble 1, M A Vadas 1
PMCID: PMC1148481  PMID: 3426563

Abstract

Tumour necrosis factor (TNF) did not stimulate lipolysis in isolated rat adipocytes, though preincubation with TNF increased adrenaline-stimulated fatty acid release. Glycogenolysis, gluconeogenesis and ketogenesis in isolated rat hepatocytes were not influenced by TNF in short-term (30-60 min) incubations. TNF stimulated 14CO2 production from [U-14C]glucose in rat hemidiaphragm preparations, but lactate production and alanine release were not significantly altered. It is concluded that TNF does not regulate short-term metabolism in adipocytes, hepatocytes and muscle preparations in the manner of a catabolic hormone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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