Extended Data Figure 5: Germline Polygenic Risk Score (PRS) enrichment of CKP tumor samples and CUP tumor samples, broken down by 8 different cancer types.

(a) Colorectal Adenocarcinoma (COADREAD), (b) Diffuse Glioma (DIFG), (c) Invasive Breast Carcinoma (BRCA), (d) Melanoma (MEL), (e) Non-Small Cell Lung Cancer (NSCLC), (f) Ovarian Epithelial Tumor (OVT), (g) Prostate Adenocarcinoma (PRAD), and (h) Renal Cell Carcinoma (RCC). The magnitude of the enrichment is quantified by ${\stackrel{\mathrm{ˆ}}{\mathrm{\Delta }}}_{\text{PRS}}$: the mean difference between the concordant (i.e. OncoNPC matching) cancer type PRS and mean of PRSs of discordant cancer types (see Methods). ${\stackrel{\mathrm{ˆ}}{\mathrm{\Delta }}}_{\text{PRS}}$ is shown for CKPs in blue (for reference) and CUPs in green.