FIG. 1.

B6 CD154 k.o. mice do not develop MAIDS after LP-BM5 infection. B6 w.t. or CD154 k.o. mice infected with LP-BM5 virus were sacrificed 8 weeks later. LP-BM5-infected w.t. B6, but not CD154 k.o., mice exhibited all of the positive readouts denoting LP-BM5-induced MAIDS which were statistically different from those responses seen for uninfected mice; splenomegaly, hyper-IgG2a, and diminished or nonexistent spleen cell response to LPS or ConA stimulation. Each bar represents a value for an individual mouse. P values were derived by the Student t test and are represented as follows: ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001; NS (nonsignificant), P > 0.05. This experiment is representative of three other experiments.