Fig. 2. (A) Modification of linker attachment from previous work (compound 3; sulfur linker) led to the discovery of a new versatile exit vector (compound 4; amide linker), and the diethylglycine moiety as the centerpiece hub in red. (B) Docking poses of compounds 10b (magenta sticks) and 11b (blue sticks) within active (green; PDB: 6KPF) and inactive (orange; PDB: 5ZTY) states of CB2R, respectively. The red dashed line indicates the approximate boundary of the lipid bilayers. For a detailed description of the docking studies see ESI, S3.†.
