Figure 7.

(A) Kinetic barrier diagram^71,72 of the SIP model. (B) Large ${\left[\text{E}\right]}_0$ regime, which enables the determination of $k_{\text{I}}$. (C) Small ${\left[\text{E}\right]}_0$ regime, which enables the determination of $k_{\text{cat}}$ and $K_{\text{M}}$ once $k_{\text{I}}$ is known. In panel C, $\left[\text{A}\right]=\left[\text{I}\right]+\left[\text{P}\right]$, as in eq 4.