Table 1. Comparison of the demographic characteristics, and LV and RV function between the D-TGA patients and controls.
| Parameters | D-TGA (n=34) | Control (n=17) | P |
|---|---|---|---|
| Demographic | |||
| Age at CMR scan (years) | 9.5 [6.4, 13.7] | 10.0 [8.5, 11.9] | 0.622 |
| Time after primary repair (years) | 8.3 [4.8, 12.2] | – | – |
| Gender, M/F (n) | 20/14 | 10/7 | >0.99 |
| Height (cm) | 125 [111.5, 152] | 148 [137, 153] | 0.013 |
| Weight (kg) | 23.35 [18.72, 37.5] | 39 [29.2, 46.5] | 0.015 |
| Body surface area (m2) | 0.9 [0.6, 1.1] | 1.27 [1.1, 1.4] | 0.001 |
| Heart rate (bpm) | 70.5 [60.8, 81.5] | 77.0 [73.0, 93.5] | 0.022 |
| Transposition type | |||
| D-TGA-IVS | 14 [41] | – | – |
| D-TGA-VSD | 20 [59] | – | – |
| Cases with re-intervention | 5 [15] | – | – |
| Echocardiographic parameters | |||
| Aortic dilatation | 25 [73] | ||
| Supravalvular pulmonary stenosis (m/s) | 2.3 [1.8, 2.7] | ||
| Mild | 12 [35.2] | ||
| Moderate | 3 [8.8] | ||
| Severe | 1 [2.9] | ||
| Obstruction of the pulmonary artery (mmHg) | 17.0 [9.8, 31.5] | ||
| Mild | 18 [53] | ||
| Moderate | 5 [14.7] | ||
| Severe | 2 [5.8] | ||
| LV function | |||
| LV EDV index (mL/m2) | 79.8 [75.2, 90.0] | 75.7 [64.8, 89.3] | 0.304 |
| LV ESV index (mL/m2) | 32.0 [29.6, 36.0] | 29.0 [27.8, 36.0] | 0.405 |
| LV SV index (mL/m2) | 49.4 [43.9, 55.0] | 46.6 [40.4, 54.8] | 0.426 |
| LV ejection fraction (%) | 60.5 [55.4, 63.7] | 61.1 [56.5, 64.0] | 0.976 |
| LV mass index (g/m2) | 42.8 [38.7, 50.0] | 42.7 [34.7, 47.8] | 0.300 |
| RV function | |||
| RV EDV index (mL/m2) | 85.3 [76.4, 96.5] | 82.8 [78.2, 94.6] | 0.865 |
| RV ESV index (mL/m2) | 33.4 [28.9, 38.2] | 36 [32.2, 43.1] | 0.255 |
| RV SV index (mL/m2) | 49.7 [43.3, 60] | 48.4 [45.3, 52.4] | 0.410 |
| RV ejection fraction (%) | 59.0 [55.3, 61.6] | 56.1 [53.6, 59.6] | 0.135 |
| RV mass index (g/m2) | 26.37 [22.99, 35.06] | 27.45 [24.32, 31.23] | 0.988 |
| RVEDV/LVEDV ratio | 1.03 [0.96, 1.13] | 1.10 [1.03, 1.17] | 0.485 |
| Valve regurgitation and late gadolinium enhancement | |||
| Aortic valve regurgitation | 24 [70.6] | – | – |
| Pulmonary valve regurgitation | 32 [94.1] | – | – |
| Myocardial delayed enhancement | 2 [6] | ||
The data are presented as the median [IQR] or n [%]. IQR = [25th percentile, 75th percentile]. LV, left ventricle; RV, right ventricle; D-TGA, dextro-transposition of the great arteries; CMR, cardiovascular magnetic resonance; M/F, male/female; IVS, intact ventricular septum; VSD, ventricular septal defect; EDV, end-diastolic volume; ESV, end-systolic volume; SV, stroke volume; RVEDV, right ventricle end-diastolic volume; LVEDV, left ventricle end-diastolic volume; IQR, interquartile range.