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. 2024 Sep 6;20(10):6881–6895. doi: 10.1002/alz.14154

FIGURE 1.

FIGURE 1

AD pathologies and digital cognitive assessments differentiate by diagnosis. (A) Cortical Aβ is increased in MCI (yellow) and AD (red) compared to CN (blue) older adults. (B) EC tau SUVR is increased in MCI compared to CN and further increased in AD compared to MCI. (C) Performance on digital cognitive battery declines in MCI with further impairment in AD. Effect sizes for cortical Aβ (blue), EC tau (green), and performance on digital cognitive assessment (maroon) between (D) CN and MCI, (E) MCI and AD, and (F) CN and AD. (G) ROC curves show that AD pathologies and performance on digital cognitive assessment can each differentiate CN and MCI, but the digital cognitive assessment was reliably better than the other two measures. (H) ROC curves demonstrating that only the digital cognitive assessment and EC tau can differentiate MCI and AD. (I) Each measure reliably differentiates CN from AD.