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. 2024 Aug 27;20(10):7090–7103. doi: 10.1002/alz.14194

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© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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CSF YKL‐40 correlates with microglial and astrocytic genes. Shown are the hub genes for the astrocytic and microglial (DAM) modules, with astrocytic genes highlighted for the astrocytic module and microglial genes highlighted for the microglial (DAM) module. Both modules correlate with CSF YKL‐40. The mean gene expression vector of the astrocytic genes from the astrocytic module and microglial genes from the microglial (DAM) module also correlate with YKL‐40, supporting a role for these genes in the relationship between brain pathophysiology and CSF YKL‐40. See, Table S10 for hub gene analysis. DAM, disease‐associated microglia.