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23ME-00610 exhibits minimal cross-reactivity to cynomolgus CD200R1 ortholog (MfCD200R1). (a) Binding of 23ME-00610 to MfCD200R1 or hCD200R1 over-expressed on Expi293 cells was evaluated by flow cytometry. (b) Sequence alignment of the extracellular domains of hCD200R1-iso4-ref and MfCD200R1 (UniProt: G7NZT0) with dots indicating identical sequence. hCD200R1 residues with atoms within 5Å of 23ME-00610 in the solved structure are shaded in cyan.
