Table 1.
Tumor types subjected to FLASH radiotherapy
| Tissue | Species | Tumor type | Radiation modality | Total dose(s) (Gy) | Mean dose rate (Gy/s) | Reference |
|---|---|---|---|---|---|---|
| Blood/lymph | Murine host | Patient-derived xenograft: CD7+ and CD45+ cells (human T-ALL) | Electron (6 MeV) | 4 | 200 | Chabi et al. 2021 |
| Human | Spontaneous: CD30+ T cell cutaneous lymphoma | Electron (5.6 MeV) | 15 | 166 | Bourhis et al. 2019 | |
| Brain | Murine/murine host | Orthotopic: isogenic H454, human U87 glioblastoma | Electron (6 MeV) | 10, 14, 25, 30 | 2.5 × 103 −7.8 × 106 | Montay-Gruel et al. 2021 |
| Rat | Orthotopic: xenograft NS1 glioblastoma | Electron (10 MeV) | 16, 25 | 66–74 | Liljedahl et al. 2022 | |
| Breast | Murine | Isogenic: EMT6 breast cancer in BALB/c mice | High-energy X-rays | 18 | 1,000 | Gao et al. 2022 |
| Murine | Isogenic: breast cancer in C3H mice | Proton (250 MeV) | 40–60 | 71–89 | Sorensen et al. 2022 | |
| Murine host | Xenograft: HBCx-12A (human breast cancer) | Electron (4.5 MeV) | 17 | ≥40 | Favaudon et al. 2014 | |
| Murine host | Xenograft: MDA-MB 231 (human breast cancer) | Electron (10 MeV) | 10, 20, 1930 | 90, 180, 270 | Cao et al. 2021 | |
| Gut | Murine | Isogenic: flank pancreatic tumor MH641905 | Proton (230 MeV) | 12, 15, 18 | 80 | Diffenderfer et al. 2020 |
| Murine | Isogenic: flank pancreatic tumor MH641905 | Proton (230 MeV) | 18 | 106–118 | M.M. Kim et al. 2021 | |
| Head & neck | Murine | Isogenic: oral carcinoma cell line | Proton (250 MeV) | 15 | 50–115 | Cunningham et al. 2021 |
| Murine host | Xenograft: Hep-2 (human head and neck carcinoma) | Electron (4.5 MeV) | 15, 20, 25 | ≥40 | Favaudon et al. 2014 | |
| Feline | Spontaneous: squamous cell carcinoma | Electron (5.5 MeV) | 25, 27, 28, 31, 34, 41 | 300 | Vozenin et al. 2019a | |
| Feline | Spontaneous: squamous cell carcinoma | Electron (5.5 MeV) | 30 | 1,500 | Rohrer-Bley et al. 2022 | |
| Lung | Murine | Orthotopic: isogenic TC-1 (lung carcinoma) | Electron (4.5 MeV) | 15, 23, 28 | ≥40 | Favaudon et al. 2014 |
| Murine | Isogenic: Lewis lung carcinoma | Electron (16 MeV) | 15 | 350 | Y.E. Kim et al. 2021 | |
| Muscle/bone | Murine | Isogenic: orthotopic and subcutaenous fibrosarcoma | Proton (230 MeV) | 12, 30 | 69–124 | Velaloupoulou et al. 2021 |
| Canine | Spontaneous: osteosarcoma | Proton (230 MeV) | 4, 8, 12 | 103 (range 61–128) | Velaloupoulou et al. 2021 | |
| Ovary | Murine | Orthotopic: isogenic ID8 or UPK10 | Electron (16 MeV) | 14 | 210 | Eggold et al. 2022 |
| Murine | Orthotopic: isogenic ID8 ovarian cancer | Electron (16 MeV) | 14 | 216 | Levy et al. 2020 | |
| Various | Canine | Spontaneous: carcinoma, sarcoma, mast cell, melanoma | Electron (10 MeV) | 15, 20, 25, 30, 35 | 430–500 | Konradsson et al. 2021 |
Abbreviation: T-ALL, T cell acute lymphoblastic leukemia.